Manufactured By                                 Latin Name
Dr. JPG Organics                               Withania Somnifera

Introduction
Withania somnifera or Ashwagandha has been extensively used in Ayurvedic medicine for their therapeutic benefits. It is popularly cultivated in India, parts of Africa and the Middle East regions. This medicinal herb acts as an adaptogen (help body adapt to stress naturally) strengthening the immune system against biological and physical stress. It can also boost general health and alleviate anxiety and stress symptoms. Ashwagandha can protect against fatigue, skin conditions, pain, diabetes, epilepsy and arthritis. (1,2)

ASHWAGANDHA AND CANCER
Extensive studies have been carried out on ashwagandha powder to understand its anti-cancer properties. Studies on ashwagandha powder have revealed that bioactive molecules present in the ashwagandha powder can effectively prevent carcinogenesis (transformation of normal cells into cancer cells). In experimentation models, ashwagandha powder has also demonstrated other anti-tumour properties. Accoring to studies, Ashwagandha powder also has proved beneficial to treat stress symptoms associated with cancer treatment. (1,3)

RESEARCH

1. A study demonstrated the tumour-inhibitory properties of ashwagandha powder in in-vitro tumour formation assays of nude mice. It was observed through molecular analysis of p53 function, that growth arrest and apoptosis take place in those selective tumour cells. (4)
2. A collaborative study published in the Journal of Experimental and Clinical Cancer Research, IIT Delhi revealed that ashwagandha have the ability to provide wild-type p53 tumour suppressor activity in cancers which have certain types of mutations present. (5)
3. A study published in 2011 observed that ashwagandha powder provided significant protection against urethane-induced lung adenoma in mice. It showed controlled protection against uterine fibroids and dermatosarcoma. (6)

EAT AS PER YOUR WEIGHT
The dosage of ashwagandha powder can range from 125mg to 5g daily, however, it should not be consumed all at once but distributed two-four times throughout the day. The powder can be blended into smoothies and hot beverages. You can even experiment with different ingredients to mask the unique smell and taste of ashwagandha powder.

Ashwagandha powder is a supplement and therefore its dosage is loosely guarded by U.S. Food and Drug Administration. It is essential to purchase ashwagandha powder from a trusted source. (7)

STORAGE
It is essential to store the ashwagandha powder in air-tight glass jars. The shelf life of ashwagandha powder is about a year. You can even use a pouch of salt to absorb the moisture away. It is advised not to refrigerate ashwagandha powder as extreme temperature denatures the preparation of the powder. (8)

SIDE EFFECTS (9)
The ill-effects of un-recommended consumption of ashwagandha include;

1. Nausea, diarrhoea, Upset stomach, Vomiting
2. Vertigo and drowsiness
3. Congested chest and cough
4. Blurred vision and dry mouth
5. Development of allergic reactions
6. Hallucinations
7. In some cases, liver damage

REFERENCE

1. The Truth about Ashwagandha and Cancer: Answers from an MSK Expert
   https://www-mskcc-org.cdn.ampproject.org/v/s/www.mskcc.org/news/truth-about-ashwagandha?amp_js_v=a6&amp_gsa=1&amp&usqp=mq331AQKKAFQArABIIACAw%3D%3D#aoh=16596022107677&referrer=https%3A%2F%2Fwww.google.com&amp_tf=From%20%251%24s&ampshare=https%3A%2F%2Fwww.mskcc.org%2Fnews%2Ftruth-about-ashwagandha
2. What are the benefits of ashwagandha?
   https://www.medicalnewstoday.com/articles/318407
3. Withania somnifera: from prevention to treatment of cancer
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899165/
4. Selective Killing of Cancer Cells by Leaf Extract of Ashwagandha: Identification of a Tumor-Inhibitory Factor and the First Molecular Insights to Its Effect
   https://aacrjournals.org/clincancerres/article/13/7/2298/182440/Selective-Killing-of-Cancer-Cells-by-Leaf-Extract
5. Ashwagandha can treat cancer: DAILAB@IIT Delhi researchers
   https://m-economictimes-com.cdn.ampproject.org/v/s/m.economictimes.com/news/science/ashwagandha-can-treat-cancer-dailabiit-delhi-researchers/amp_articleshow/68301627.cms?amp_js_v=a6&amp_gsa=1&usqp=mq331AQKKAFQArABIIACAw%3D%3D
6. An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/
7. Ashwagandha dosage: how much to take per day
   https://ro.co/health-guide/ashwagandha-dosage/
8. How and where do you keep Ashwagandha Churna?
   https://www.quora.com/How-and-where-do-you-keep-Ashwagandha-Churna
9. Ashwagandha: Uses, Benefits & Side Effects
   https://pharmeasy-in.cdn.ampproject.org/v/s/pharmeasy.in/blog/ayurveda-uses-benefits-side-effects-of-ashwagandha/amp/?amp_js_v=a6&amp_gsa=1&usqp=mq331AQKKAFQArABIIACAw%3D%3D#aoh=16596179630544&referrer=https%3A%2F%2Fwww.google.com&amp_tf=From%20%251%24s&ampshare=https%3A%2F%2Fpharmeasy.in%2Fblog%2Fayurveda-uses-benefits-side-effects-of-ashwagandha%2F